Publications
Original Articles
Castrén M#, Hotulainen P#, Vanni S#.
Synapsien karsiutumisen merkitys autismikirjon häiriössä.
(2021) Duodecim 137:711-720. [Duodecim]
#equal contribution
Abouelezz A, Stefen H, Segerstråle M, Micinski D, Minkeviciene R, Lahti L, Hardeman EC, Gunning PW, Hoogenraad CC, Taira T, Fath T, Hotulainen P.
Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment.
(2020) iScience 23(5):101053. [PubMed]
Abouelezz A, Hotulainen P.
NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186.
(2020) J Cell Biol. 219(2). [PubMed]
Minkeviciene R, Hlushchenko I, Virenque A, Lahti L, Khanal P, Rauramaa T, Koistinen A, Leinonen V, Noe FM, Hotulainen P.
MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning.
(2019) Front Mol Neurosci. 12:276. [PubMed]
Hlushchenko I, Hotulainen P.
Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines.
(2019) Biol Chem. 400(9):1129-1139.[PubMed]
Abouelezz A, Micinski D, Lipponen A, Hotulainen P.
Sub-membranous actin rings in the axon initial segment are resistant to the action of latrunculin.
(2019) Biol Chem. 400(9):1141-1146.[PubMed]
Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen P.
ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons.
(2018) Front Cell Neurosci. 12:217.[PubMed]
Pryazhnikov E, Mugantseva E, Casarotto P, Kolikova J, Fred SM, Toptunov D, Afzalov R, Hotulainen P, Voikar V, Terry-Lorenzo R, Engel S, Kirov S, Castren E, Khiroug L.
Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine.
(2018) Sci Rep. 8(1):6464.[PubMed]
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M.
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
(2017) J Neuroinflammation. 14(1):215.[PubMed]
Hotulainen P, Saarikangas J.
The initiation of post-synaptic protrusions.
(2016) Commun Integr Biol. 9(3).[PubMed]
Bertling E, Englund J, Minkeviciene R, Koskinen M, Segerstråle M, Castrén E, Taira T, Hotulainen P.
Actin Tyrosine-53-Phosphorylation in Neuronal Maturation and Synaptic Plasticity.
(2016) J Neurosci 36(19):5299-313.[PubMed]
Saarikangas, J., Kourdougli, N., Senju, Y., Chazal, G., Segerstråle, M., Kuurne, J., Minkeviciene, R., Mattila, P.K., Garrett, L., Hölter, S.M., Becker, L., Racz, I., Hans, W., Klopstock, T., Wurst, W., Zimmer, A., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., von Ossowski, L., Taira, T., Lappalainen, P., Rivera, C., Hotulainen, P.
MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation.
(2015) Dev Cell. 33(6):644-59. [PubMed]
Llano, O., Smirnov, S., Soni, S., Golubtsov, A., Guillemin, I., Hotulainen, P., Medina, I., Nothwang, H.G., Rivera, C., Ludwig, A.
KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX.
(2015) J Cell Biol. 209(5):671-686.[PubMed]
Koskinen, M., Hotulainen, P.
Measuring F-actin properties in dendritic spines.
(2014) Front Neuroanat. 8:74.[PubMed]
Koskinen, M., Bertling, E., Hotulainen, R., Tanhuanpää, K., Hotulainen, P.
Myosin IIb controls actin dynamics underlying the dendritic spine maturation.
(2014) Mol Cell Neurosci. 61C:56-64.[PubMed]
Bertling, E., Ludwig, A., Koskinen, M., Hotulainen, P.
Methods for three-dimensional analysis of dendritic spine dynamics.
(2012) Methods in enzymology. 506:391-406. [PubMed]
Koskinen, M., Bertling, E., Hotulainen, P.
Methods to measure actin treadmilling rate in dendritic spines.
(2012) Methods in enzymology. 505:47-58.[PubMed]
Tojkander S, Gateva G, Schevzov G, Hotulainen P, Naumanen P, Martin C, Gunning PW, Lappalainen P.
A molecular pathway for myosin II recruitment to stress fibers.
(2011) Curr Biol. 21(7):539-50.[PubMed]
Skwarek-Maruszewska A, Hotulainen P, Mattila PK, Lappalainen P.
Contractility-dependent actin dynamics in cardiomyocyte sarcomeres.
(2009) J Cell Sci. 122(Pt 12):2119-26.[PubMed]
Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., Lappalainen, P.
Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis.
(2009) J. Cell Biology 185:323-339.[PubMed]
Klaavuniemi T, Alho N, Hotulainen P, Kelloniemi A, Havukainen H, Permi P, Mattila S, Ylänne J.
Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of alpha-actinin.
(2009) BMC Cell Biol. 10:22.[PubMed]
Reviews
Joensuu M, Lanoue V, Hotulainen P.
Dendritic spine actin cytoskeleton in autism spectrum disorder.
(2018) Prog Neuropsychopharmacol Biol Psychiatry. 84(Pt B):362-381.[PubMed]
Bertling E, Hotulainen P.
New waves in dendritic spine actin cytoskeleton: From branches and bundles to rings, from actin binding proteins to post-translational modifications.
(2017) Mol Cell Neurosci. 84:77-84.[PubMed]
Hlushchenko I, Koskinen M, Hotulainen P.
Dendritic spine actin dynamics in neuronal maturation and synaptic plasticity.
(2016) Cytoskeleton (Hoboken). 73(9):435-41.[PubMed]
Abou Elezz, A., Minkeviciene, R., Hotulainen, P.
Basic Biology of Dendrites: Cytoskeletal organization - actin.
(2016) Chapter In "Dendrites: Development and Disease"
Hotulainen, P. and C. C. Hoogenraad.
Actin in dendritic spines: connecting dynamics to function.
(2010) J Cell Biol. 189(4):619-29.[PubMed]