August 16, 2019
PhD Defense –Iryna Hlushchenko
Actin regulation in dendritic spines:
from synaptic plasticity to animal behavior and human neurodevelopmental disorders.
Opponent Marina Mikhaylova, University Medical Center Hamburg-Eppendorf, Germany
We were happy to host Marina Mikhaylova as an opponent! Marina was very well prepared and did excellent questions but Iryna showed her skills and gave also excellent answers!
Thank you Marina and congratulations Iryna! Thank you also to Juha Voipio, who served as an official custos.
PhD work of Iryna was based on three original publications and one review article:
1) Hlushchenko I, Koskinen M, Hotulainen P. (2016) Dendritic spine actin dynamics in neuronal maturation and synaptic plasticity. Cytoskeleton 73:435-41.
2) Hlushchenko I, Hotulainen P. (2019) Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines. Biol Chem. 400:1129-1139.
3) Minkeviciene R, Hlushchenko I, Virenque A, Lahti L, Khanal P, Rauramaa T, Koistinen A, Leinonen V, Noé FM, Hotulainen, P. (2019) MIM-Deficient Mice Exhibit
Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning. Frontiers in Mol. Neurosci. 12, 276.
4) Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen P. (2018) ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic
Spines and Inhibitory Synapses in Cultured Hippocampal Neurons. Front Cell Neurosci.12:217.