August 11, 2023
PhD Defense – Pushpa Khanal
Molecular regulation of the dendritic spine initiation
Opponent Professor Martin Korte, Technische Universität Braunschweig, Germany
We were honoured to have Martin Korte as an opponent! Thank you Martin and congratulations Pushpa! Thank you also to Juha Voipio, who served as an official custos.
PhD work of Pushpa Khanal was based on four original publications:
1) Rimante Minkeviciene, Iryna Hlushchenko, Anaïs Virenque, Lauri Lahti, Pushpa Khanal, Mikko Kettunen, Tuomas Rauramaa, Arto Koistinen, Riikka Immonen, Ville Leinonen, Francesco M. Noé, and Pirta Hotulainen. “MIM-deficient mice exhibit anatomical changes in dendritic spines, cortex volume and brain ventricles, and functional changes in motor coordination and learning.” Frontiers in Molecular Neuroscience. 12:276, 2019.
2) Pushpa Khanal and Pirta Hotulainen. “Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BARDomain Proteins.’’ Cells. 10(9):2392, 2021.
3) Pushpa Khanal, Zoran Boskovic, Lauri Lahti, Aruna Ghimire, Rimante Minkeviciene, Patricio Opazo, Pirta Hotulainen. ‘‘Gas7 is a novel dendritic spine initiation factor.’’ eNeuro. ENEURO.0344- 22.2023, 2023.
4) Iryna Hlushchenko, Pushpa Khanal, Amr Abouelezz, Ville O. Paavilainen, Pirta Hotulainen. “ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons.” Frontiers in Cellular Neuroscience. 12:217, 2018.